Model Based Systems Engineering (MBSE) is becoming increasingly recognized as a critical enabler for significantly improving the effectiveness and efficiency of systems engineering. While MBSE is seeing significant growth in its application to complex system development programs, this application has largely been constrained to the context of individual programs. In other words, MBSE is being used primarily to improve outcomes of individual programs within an enterprise. While this can be of sufficient value to make the investment worthwhile, significantly greater value could be obtained by an enterprise by integrating the individual MBSE efforts and capabilities being developed for its programs into a more coherent enterprise-level MBSE effort. The collection and aggregation of local pockets of knowledge into an integrated global body of knowledge can enable the enterprise to better act as a unified enterprise with speed and agility through use of MBSE-enabled Enterprise Systems Engineering (ESE) processes and methods. This paper will describe some of the principles and methods that should be employed to improve the ability of local MBSE efforts to contribute to the execution of ESE.